Human Herpesvirus-6 (HHV-6)


Immunohistochemistry
   Transplant
   Infertility
Chromosomal Integration
HHV-6 PCR DNA

Most people acquire HHV-6 early in life where it usually remains in a latent state for the lifetime of the host. However, viral reactivation can occur at any time and cause serious complications in cases of transplantation and immune suppression.

IHC - HHV-6 in Secretory Ducts

HHV-6 Immunohistochemistry

Immunohistochemical staining of tissues (IHC) is useful when analyzing tissue samples for active herpesvirus infections. The detection of HHV-6 late viral protein expression in tissues is definitive proof of active viral infection. Read more information on how IHC can be utilized in Transplant and Infertility:

IHC in Transplant

IHC in Infertility

DNA Strand with HHV-6 Chromosomal Integration

Chromosomally Integrated HHV-6 (ciHHV-6)

Chromosomal Integration of HHV-6 (ciHHV-6) occurs in 0.5-2% of the population. The presence of the viral genome integrated into all body cells can confound diagnostic interpretation of HHV-6 DNA present in the blood, leading to a misdiagnosis of HHV-6 reactivation and unnecessary anti-viral treatment. Read more information on ci-HHV-6:

ci-HHV-6

HHV-6 PCR DNA - Quantitative Analysis

HHV-6 PCR DNA — Quantitative Analysis

Measuring the viral DNA in the blood is the standard method used to determine HHV-6 reactivation and likelihood of ci-HHV-6. Coppe Laboratories offers quantitative HHV-6 testing through blood, plasma, and cerebrospinal fluid (CSF). For confirmed ci-HHV-6 status, PCR testing on hair follicles or nail clippings is recommended.