Arthropod-Borne Diseases

tick warning sign

Coppe Laboratories’ Arthropod-Borne Disease Panel detects 98% of the most common arthropod-borne infections in the U.S.

Ticks and mosquitoes are responsible for transmitting the most common arthropod-borne infections in the U.S. Arthropods can carry and transmit bacteria, viruses, and parasites to humans. Co-infection is not uncommon.

Clinical diagnosis is necessary to identify what pathogens have been transmitted in order to prescribe appropriate treatment.

Coppe Laboratories’ Arthropod-Borne Disease Panel includes Lyme Borrelia, West Nile Virus, Anaplasma, Babesia, and Powassan Virus (POWV).* Though few cases of POWV are reported each year in the United States, serious complications can include neurologic problems, encephalitis, and even death.

Arthropod-borne Disease Panel Test Menu

*While comprehensive panel testing is a useful diagnostic tool, all tests can be ordered separately.


Lyme disease is the most common vector-borne disease in the United States. Symptoms can include fever, muscle aches, fatigue, and joint pain. This bacterial infection is commonly treated with a prescribed course of antibiotics.

Coppe Laboratories’ confirmatory immunoblot takes the guess work out of result interpretation. Computer-generated and semi-quantitative, the immunoblot reports specific bands and optical density as illustrated below.

Coppe Immunoblot Report

Konstance K. Knox, PhD, Founder and CEO of Coppe Laboratories, discusses Coppe Laboratories’ Lyme testing:

Powassan Virus

Powassan Virus (POWV) is a member of the same family of viruses as West Nile Virus, Dengue Fever, Zika, and Hepatitis C. and is found mostly in the northeast United States as well as the Great Lakes area.

Symptoms of POWV infection are very similar to those of Lyme disease, but reportedly can be more severe. The Powassan virus attacks the nervous system and can cause encephalitis.Serious infections can result in muscle weakness, headache, confusion and even seizures. Ten percent of POWV encephalitis infections are fatal. Long-term neurologic effects that mimic those of Post-Treatment Lyme Disease Syndrome (PTLDS) have been reported.

Published in 2016 by Coppe Laboratories, “A Guide to the Powassan Virus” provides general background information about Powassan Virus (POWV), describes collaborative studies done by Coppe Laboratories, and presents case studies for examination. You can read a Guide to the Powassan Virus here.


Anaplasmosis, previously known as Human Granulocytic Ehrlichiosis (HGE), is caused by the bacterium Anaplasmaphagocytophilum. Clinical symptoms can be non-specific, but typically include headaches, fever, chills, malaise and muscle aches. Without laboratory testing, the disease can be impossible to distinguish from Lyme disease, Ehrlichiosis, and other tick-borne illnesses.


Babesiosis is commonly caused by the parasite Babesia microtiand less frequently by the closely related Babesia duncani. While the severity of Babesia infections can vary, most individuals present with flu-like symptom such as irregular fevers, chills, headache, nausea, body aches and fatigue.In severe cases, the disease can cause hemolytic anemiaas the parasites infect and destroy red blood cells. Antibiotics alone will not treat Babesia, and the disease can be life-threatening in immunocompromised patients.

West Nile Virus (Mosquito-Borne)

West Nile Virus (WNV) is a member of the Flaviviridae family and is transmitted by an infected mosquito. This group of viruses includes the familiar Zika virus, Dengue Fever, Powassan virus, Hepatitis C and tick-borne encephalitis viruses (TBEV). Symptoms can include fever, headache, muscle weakness, confusion, and seizures.

POWV (#3008) + WNV (#5000)
As Powassan Virus and West Nile Virus are from the same family group (Flaviviridae), chronic neurological symptoms can present themselves similarly.If a tick bite is not confirmed, pairing these two tests on an order may aid in diagnosis for the patient presenting with chronic symptoms who has previously been tested for Lyme and other co-infections.
New York Physicians: No approved waiver necessary. Coppe Laboratories holds a license with the NYSDOH (#PFI 9230) and is permitted to accept orders for the following tests: #3008 Powassan Virus IgG/IgM; #5000 West Nile Virus IgM; #2001 HHV 6 IHC; #20011 HHV 6 IHC (Endometrial)

Arthropod-Borne Individual Test Menu