Women’s Health & Infertility

  • HHV-6 in Infertility

    Human herpesvirus 6 (HHV-6) is suspected to be involved in several types of gestational complications, including spontaneous abortions, gestational hypertension and preterm birth. According to a study published in PLOS Pathogens (Marci R, et al, 2016) HHV-6A is found in 43% of women with unexplained infertility. The ability of HHV-6 to disrupt the uterine environment and fetal development may result in infertility and pregnancy loss. The virus can only be detected in uterine epithelial cells and not in blood samples using traditional HHV-6 testing methods.

    Coppe Laboratories’ IHC testing for HHV-6 has proven to be the most sensitive method for detection of active viral replication in tissue samples. With the growing evidence of an association between HHV- 6 and infertility, we recommend testing endometrial tissue from patients presenting with unexplained infertility, repeat failure to implant and multiple miscarriages.


    1. Marci R et al. (2016) Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility. PLoS ONE 11(7): e0158304.
    1. Eliassen et al. Med Hypotheses. 2017 May;102:41-47.