News & Events

Powassan Guide Available

The Powassan Guide is a monograph published by Coppe Laboratories that provides information on another tick-borne pathogen, the Powassan virus.  This virus belongs to the same virus family as Zika and West Nile, but unlike those, it is transmitted by a tick and not a mosquito.  Recent news articles have alerted the public to the increased incidence of the Powassan virus.  Because symptoms related to infection with this virus are similar to a number of tick-borne diseases, including Lyme, it…

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Cape Cod Times Reports New Information On Powassan Virus Incidence

Dr. Knox, CEO of Coppe Laboratories, was interviewed by reporter, Cynthia McCormick of the Cape Cod Times for an article published Sunday, August 14, 2016 (full article here). In her interview, Dr. Knox reported a 10.4% incidence of Powassan virus in clinical samples from several sites in Wisconsin.  The study was the collaborative work of the Marshfield Clinic (WI), the Medical College of Wisconsin and the New York State Department of Health. Powassan virus was found as a co-infection with Lyme disease…

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HHV-6A Infection of the Uterus Linked to Infertility

HHV-6A Found in Women with Unexplained Infertility HHV-6A was found in 43% of women with unexplained infertility, according to a study published in PLOS Pathogens. (Marci R, et al, 2016.) The study authors found that the virus was present in uterine epithelial cells only, and not the blood. 30 infertile women and 36 fertile (control) women participated in the study. HHV-6B was found in equal amounts in the blood of patients and controls. Secondary endpoints noted the correlation between estradiol…

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Local Governments Launch Tick-Borne Illness Awareness Campaigns

As pleasant summer weather entices people to spend more time outdoors, ticks are also out in full force, looking to attach to a host. In New York City, the Department of Health launched a campaign on June 9 to increase public awareness of ticks and the many diseases they carry. A children’s workbook with a dog named "Tick Check Harry" teaches children how to identify and remove ticks from themselves. It is available on the NY website: http://www1.nyc.gov/site/doh/health/health-topics/ticks.page In Pike County, Pennsylvania, the Tick-Borne Illness Task Force is working…

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Painless Knee Effusion as Early Sign of Lyme Disease

Early symptoms of Lyme disease are not always obvious, including the notorious erythema migrans ("bullseye") rash, which is seen in only a subset of patients. Thus, knowing additional signs of the disease is important. A November 2015 study by the American Academy of Orthopedic Surgeons suggests knee effusions, or “water on the knee,” might be an indicator of the disease even in the absence of the rash and a known tick bite. Musculoskeletal complaints are frequently associated with Lyme disease…

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Coppe Laboratories’ Lyme Testing Includes European Strains of Borrelia

Borrelia burgdorferi and Borrelia mayonii are the primary bacteria that cause Lyme Disease in the United States. Two other strains, Borrelia afzelii and Borrelia garinii, are the primary causes of Lyme disease in Europe and Asia. In a recent “Hot Topic” from the Mayo Clinic’s Dr. Elli Theel, a recommendation of using European immunoblots was recommended for individuals traveling outside the United States.  Wisconsin-based Coppe Laboratories is the only commercial reference laboratory in the U.S. that currently uses European immunoblots to detect…

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Coppe Laboratories Announces New Powassan Virus Testing for Patients with Tick Exposure

Coppe Laboratories has announced the availability of testing for a tick-associated virus, the Powassan Virus (POWV). Transmitted by the tick known to carry Lyme disease bacteria, the POWV is a member of the family of viruses that include such familiar names as Zika, West Nile, and Yellow Fever. Coppe Laboratories is the first commercial laboratory to provide POWV testing, which will include both a direct and indirect test. Symptoms associated with POWV are similar to those of Lyme disease, but…

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Direct and Indirect Powassan Virus Testing

Coppe Laboratories Powassan Virus testing includes both a direct and indirect test.  A simple blood sample is all that is required.  The direct test (PCR) will detect acute infection and the indirect test (IFA) provides evidence of viral exposure. The picture at the left represents a positive POWV. Powassan virus is carried by the same tick that causes Lyme disease.  Unlike Lyme Borrelia, however, the virus is transmitted within 15 minutes of tick attachment making it unique among tick-borne pathogens in…

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Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman

Coppe Laboratories novel immunohistochemistry (IHC) technology for diagnosing life threatening HHV-6 associated organ disease was profiled in a recent publication in the Journal of Clinical Virology (J Clin Virol. 2015 Dec 14;75:27-32, http://www.ncbi.nlm.nih.gov/pubmed/26745830.)  In collaboration with the University of Chicago we describe the case of a previously healthy woman who presented with a skin rash, mild upper respiratory symptoms, and succumbed to fulminant hepatic failure that was attributed to infection with HHV-6B by immunohistochemistry. The review of the literature showed…

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A fatal case of acute HHV-6 myocarditis following allogeneic haemopoietic stem cell transplantation

Waukesha, WI, The November issue of the Journal of Clinical Virology (J Clin Virol. 2015 Nov; 72:82-4. doi: 10.1016/j.jcv.2015.09.013. Epub 2015 Oct 9) reports the first fatal case of biopsy-proven HHV-6 myocarditis post stem cell transplant. Dr. David Baewer, Chief Medical Officer at Coppe Laboratories co-authored the paper with colleagues from Sydney, Australia. The publication reports the case of a 62-year old patient who underwent a matched, unrelated hematopoietic stem cell transplant. On day +13 the patient experienced cardiac failure.…

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